Azithromycin is a macrolide antibiotic that has been used for more than a decade to treat urinary tract, bronchial tract, lungs and sinuses infections. The unique pharmacokinetics of Azithromycin-rapid absorption and extensive distribution in tissue allows for short 3-day (500 mg/day for 3 days) or 5-day (500 mg on day 1 followed by 250 mg on day 2-5) course of therapy. The aim of present work was to formulate sustained released azithromycin microsphere by varying drug polymer ratio with different solvents in emulsion solvent evaporation technique to reduce the problem related to drug like insoluble in water, bitter taste and gastrointestinal side-effects. Comparative evaluation of microspheres was done by determining bulk density, tapped density, Hausner ratio, angle of repose, particle size, drug loading, in-vitro dissolution study and kinetic study.
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